FR183998 free base

CAS No. 239440-20-1

FR183998 free base ( —— )

Catalog No. M26218 CAS No. 239440-20-1

FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 621 Get Quote
10MG 893 Get Quote
25MG 1323 Get Quote
50MG 1782 Get Quote
100MG 2412 Get Quote
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Biological Information

  • Product Name
    FR183998 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
  • Description
    FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.(In Vitro):FR183998 free base has potent inhibitory effects on Na+/H+ exchanger in rat lymphocytes, rat platelets, and human platelets with IC50s of 0.3 nM, 6.5 nM, and 3.1 nM, respectively.(In Vivo):FR183998 free base (1 mg/kg, i.v.) reduces the increase in serum levels of alanine transaminase, aspartate transaminase, and lactate dehydrogenase induced by hepatic I/R, and prevents the incidences of hepatic necrosis, apoptosis, and neutrophil infiltration. FR183998 free base blocks the I/R-induced activation of the NF-κB, reduces induction of iNOS and inhibits the production of nitric oxide. FR183998 free base also decreases the expression of the iNOS gene antisense transcript in the liver of hepatic I/R rats.FR183998 free base (0.1 and 1.0 mg/kg, i.v.) shows no effect hemodynamic parameters, and does not affect mean blood pressure and heart rate in conscious rats.?Pretreatment of 0.01, 0.032, 0.10 mg/kg FR183998 free base or posttreament of 0.032 and 0.10 mg/kg FR183998 free base via intravenous administration, dose-dependently reuces reperfusion-induced ventricular fibrillation (VF) and mortality in reperfusion-induced arrhythmias in anesthetized rats, with ED50s against VF of 0.015 mg/kg and 0.070 mg/kg, respectively.?FR183998 free base also reduces myocardial infarct sizes, and suppresses the arrhythmias in anesthetized rats.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    239440-20-1
  • Formula Weight
    428.3
  • Molecular Formula
    C17H19Cl2N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN(C)CCNC(=O)c1cc(cc(c1)-c1cc(Cl)sc1Cl)C(=O)NC(N)=N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Han L, Bao X, Hu T, Du Z, Chen W, Zhu D, Liu Q, Sun M, Yang R. Novel donor-acceptor polymer containing 4,7-bis(thiophen-2-yl)benzo[c][1,2,5]thiadiazole for polymer solar cells with power conversion efficiency of 6.21%. Macromol Rapid Commun. 2014 Jun;35(12):1153-7.
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