FR183998 free base
CAS No. 239440-20-1
FR183998 free base ( —— )
Catalog No. M26218 CAS No. 239440-20-1
FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 621 | Get Quote |
|
10MG | 893 | Get Quote |
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25MG | 1323 | Get Quote |
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50MG | 1782 | Get Quote |
|
100MG | 2412 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameFR183998 free base
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NoteResearch use only, not for human use.
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Brief DescriptionFR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
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DescriptionFR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.(In Vitro):FR183998 free base has potent inhibitory effects on Na+/H+ exchanger in rat lymphocytes, rat platelets, and human platelets with IC50s of 0.3 nM, 6.5 nM, and 3.1 nM, respectively.(In Vivo):FR183998 free base (1 mg/kg, i.v.) reduces the increase in serum levels of alanine transaminase, aspartate transaminase, and lactate dehydrogenase induced by hepatic I/R, and prevents the incidences of hepatic necrosis, apoptosis, and neutrophil infiltration. FR183998 free base blocks the I/R-induced activation of the NF-κB, reduces induction of iNOS and inhibits the production of nitric oxide. FR183998 free base also decreases the expression of the iNOS gene antisense transcript in the liver of hepatic I/R rats.FR183998 free base (0.1 and 1.0 mg/kg, i.v.) shows no effect hemodynamic parameters, and does not affect mean blood pressure and heart rate in conscious rats.?Pretreatment of 0.01, 0.032, 0.10 mg/kg FR183998 free base or posttreament of 0.032 and 0.10 mg/kg FR183998 free base via intravenous administration, dose-dependently reuces reperfusion-induced ventricular fibrillation (VF) and mortality in reperfusion-induced arrhythmias in anesthetized rats, with ED50s against VF of 0.015 mg/kg and 0.070 mg/kg, respectively.?FR183998 free base also reduces myocardial infarct sizes, and suppresses the arrhythmias in anesthetized rats.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number239440-20-1
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Formula Weight428.3
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Molecular FormulaC17H19Cl2N5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESCN(C)CCNC(=O)c1cc(cc(c1)-c1cc(Cl)sc1Cl)C(=O)NC(N)=N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Han L, Bao X, Hu T, Du Z, Chen W, Zhu D, Liu Q, Sun M, Yang R. Novel donor-acceptor polymer containing 4,7-bis(thiophen-2-yl)benzo[c][1,2,5]thiadiazole for polymer solar cells with power conversion efficiency of 6.21%. Macromol Rapid Commun. 2014 Jun;35(12):1153-7.
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